Forced displacement and resettlement into a new country has reached the highest level since World War II resulting from war, organized violence, and climate related disasters around the world. The recent COVID-19 pandemic further exacerbated global displacement and insecurity. Exposure to multiple traumatic stressors and life adversities make forcibly displaced families among the most vulnerable populations. The dynamics of war/violence, poverty, political and economic instability, infectious diseases, and climate disasters are increasingly interconnected and mutually reinforcing. Forced displacement disrupts the entire ecology and family structure of refugee populations. After resettlement in a new country, cumulative daily stressors and additional exposures to traumatic stress place refugee families at risk of serious mental health and relational challenges. This workshop will focus on describing a prevention and intervention framework for guiding research directed at responding to the current human rights crisis with specific emphasis on cultural adaptation, treatment effectiveness, implementation sciences, and critical emancipatory engagement.